Activated with the antibiotic rifampicin and a variety of plant metabolites, like hyperforin, guggulipid, colupulone, and isoflavones. Reaction to unique ligands is species-distinct. Activated by Obviously transpiring steroids, for example pregnenolone and progesterone. Binds into a reaction ingredient from the promoters in the CYP3A4 and ABCB1/MDR